摘要
目的通过测定兔血小板聚集和ＴＸＢ２的含量，比较观察Ｆ、Ｉ、ＦＩ、ＦＩＳ在抗血栓方面的药理作用特点。方法用比浊法［４］和放免法［７］测定Ｆ、Ｉ、ＦＩ、ＦＩＳ在体外对兔血小板聚集及释放的ＴＸＢ２的影响。结果连有阿魏酸和吲哚美辛的载体衍生物ＦＩ，ＦＩＳ可抑制ＡＡ、ＡＤＰ诱导的血小板聚集，在１０～２５０μｍｏｌ·Ｌ－１的剂量范围内，两药的作用呈剂量依赖关系，ＦＩ、ＦＩＳ２４０μｍｏｌ·Ｌ－１对ＡＡ和ＡＤＰ诱导的兔血小板聚集的抑制率分别为５９．３２％、５８．５８％和３９．０９％、４９．５６％。ＦＩ、ＦＩＳ２４０μｍｏｌ·Ｌ－１对ＴＸＢ２产生的抑制率分别为４０．６０％、２８．７２％。结论在等分子浓度下，ＦＩ、ＦＩＳ对ＡＡ诱导的兔血小板聚集及其ＴＸＢ２和释放的抑制作用明显强于阿魏酸和吲哚美辛本身。
Objective To investigate the effect of
IndomethacinumFerulate acid(FI) and IndomethacinumFerulate acidstarch (FIS) on rabbit platelet
aggregation induced by ADP and AA and thromboxane B2production. Methods Influences of
F,I,FI,FIS on rabbit platelet aggregation and TXB2 production were assaied by born GVR and
RIA. Results Both FI and FIS 12.5,60.0,240.0 molL-1,could inhibit the rabbits platelets
aggregation induced by adenosin diphosphate (ADP,2.0molL-1),arachidonic acid (AA,33.3
molL-1).Which showed a good doseeffect relationship.The inhibitions by 10300 molL-1 were
dependent FI 25.059.32%,FIS 13.1239.09%(ADPinduced),FI 29.96%63.06%),FIS
11.47%39.56%(AAinduced).inhibit the ptoduction of TXB2 as well,(AAinduced)FI 40.60%,FIS
28.74%(240.0 molL-1)for TXB2. Conclusions There are positive correlations between the
inhibition of platelet aggregation and TXB2 and effect mechanism on speranskia tuberculata.
出处
《兰州医学院学报》
1999年第1期10-12,共3页
Journal of Lanzhou Medical College
关键词
阿魏酸
吲哚美辛
血小板聚集
血栓素B2
Ferulic acidIndomethacin,FerulicIndomethacin-target moleculeAdenosine
diphosphateArachidonic acidPlatelet aggregationTXB2
