摘要
目的 :探讨金艾康 (汉防己甲素片 )合用化学药物治疗肿瘤的临床增效作用。方法 :通过比较治疗组与对照组 (金艾康合并化学药物者为治疗组 ,单用化学药物者为对照组 ,每组各为 3 0例 )的总缓解率与毒副反应来评价金艾康对化疗药物的增效作用。结果 :治疗组与对照组的总缓解率分别为 80 %与 66.7% ,其中部分毒副反应如消化道反应与肢端麻木症状等治疗组明显低于对照组。结论 :金艾康具有对化学药物治疗肿瘤增效作用 ,其作用机理可能是逆转MDR 。
OBJECTIVE:To study the synergic effect of Jinake(Tetrandrine tablets) used together with chemical drugs in the treatment of cancer.METHOD:The total remission rate and toxicity and side effects in two groups(treated by Jinake combine with chemical drugs called treating group,treated by chemical drugs only called control group,two groups have respectively 30 patients) were compared.By this method we evaluated the synergic effect of Jinake when used together with chemical drugs in the treatment of cancer.RESULTS:The total remission rate of treating group and control group are 80% and 66.7% respectinely.Toxicity and side effects such as gastrointestinal tract reaction and numbness of the extremities of the treating group are low than those of the control group.CONCLUSION:Jinake has the synergic effect to chemical drugs in the treatment of cancer shch as malignant lymphadenoma.The mechanism may have probably reversed MDR.Moreover,it can reduce the toxicity and side effects of chemical drugs in the treatment of cancer.
出处
《中国现代应用药学》
CAS
CSCD
1999年第3期59-61,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
金艾康
缓解率
毒副作用
肿瘤
中西医结合治疗
Jinake,multidrug resistance,total remission rate,toxicity and side effects
