摘要
目的检测杏根青龙汤对慢性阻塞性肺疾病患者诱导痰细胞、IL-8和MMP-9的影响,以探讨杏根青龙汤对COPD患者气道炎症及气道重塑的影响。方法将80例稳定期COPD患者随机分为治疗组和COPD对照组。另有40例非吸烟健康志愿者作为健康对照组。所有COPD患者均接受沙美特罗替卡松粉(50μg/100μg)吸入。治疗组另给予杏根青龙汤口服。治疗前后分别检测诱导痰细胞、白细胞介素8(IL-8)和基质金属蛋白酶9(MMP-9)水平。结果治疗后,治疗组和COPD对照组诱导痰细胞总数、中性粒细胞比例和MMP-9水平均有所下降。治疗组下降的程度优于COPD对照组。治疗前后诱导痰IL-8水平无统计学差异。结论杏根青龙汤可以有效降低诱导痰细胞总数、中性粒细胞比例和MMP-9水平。
Objective To study the effects of Xinggenqinglongtang decoction on the cell counts and the levels of IL-8 and MMP-9 in induced sputum in patients with chronic obstructive pulmonary disease（COPD）.Methods A total of 80 patients with stable COPD were enrolled and randomly divided into 2 groups：test group and COPD control group.40 nonsmoke healthy individuals were enrolled in control group.All patients with COPD were treated with salmeterol/fluticasone（50ug/100ug）.The test group was treated with Xinggenqiongtang Decoction.The cell counts and the levels of IL-8 and MMP-9 were measured in all cases.Results The total cell counts and the percentage of neutrophils cell counts and sputum supernatant concentration of MMP-9 of COPD were decline in test group and COPD control group.The total cell counts and the percentage of neutrophils cell counts and sputum supernatant concentration of MMP-9 of COPD were lower in test group than that of the COPD control group after treatment.The sputum supernatant concentration of IL-8 of COPD was decline slightly in all groups.Conclusions Administration of Xinggenqiongtang Decoction decreased the total cell counts and the percentage of neutrophils cell counts and the increased expression of MMP-9.
出处
《临床肺科杂志》
2011年第1期43-44,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺疾病
慢性阻塞性
基质金属蛋白酶9
杏根青龙汤
气道重塑
pulmonary disease
chronic obstructive
matrix metalloproteinases-9
xinggenqiongtang decoction
airway remodeling
