摘要
目的：探讨绿原酸及与黄芩苷配伍后静脉推注给药在家兔体内的药代动力学规律。方法：兔子10只,分为两组,Ⅰ组耳缘静脉推注绿原酸溶液6 mg.kg-1,Ⅱ组耳缘静脉推注绿原酸6 mg.kg-1和黄芩苷90 mg.kg-1,采用HPLC测定血浆中的绿原酸浓度,用K inetic软件求算其药物动力学参数,并进行统计学分析。结果：绿原酸单用及与黄芩苷配伍静脉给药后,其药动学过程均符合二室开放模型,其主要药动学参数均有显著差异（P〈0.05）。Ⅱ组绿原酸的AUC0∞较Ⅰ组明显增大。结论：黄芩苷在一定程度上能影响绿原酸在家兔体内的药动学过程。
Objective： The objective of this paper is to investigate the pharmacokinetics of Chlorogenic acid（CA）and CA-Baicalin compound after intravenous injection（iv）in rabbits.Method： Ten rabbits were randomly divided into two groups.One group were administered CA（6 mg·kg-1） by iv,while the other were treated with CA（6 mg·kg-1）-baicalin（90 mg·kg-1）compound by iv.administration.The concentration of CA in plasma was determined by HPLC.The key parameters of pharmacokinetics were calculated and analyzed by kinetic software.Result： Both Concentration-time courses of CA alone and CA-Baicalin compound were consistent with a two-compartment model after administration.The key pharmacokinetic parameters of CA alone were significantly different from that of CA-Baicalin compound（P〈0.05）.Compared with the group treated with CA alone,the group treated with CA-Baicalin compound had dramatic increased in AUC0-∞,MRT and T1/2α.Conclusion： There are significant difference between the pharmacokinetics of CA and CA-Baicalin compound in rabbits.Baicalin has impact on the pharmacokinetics of CA in rabbits.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第24期3291-3293,共3页
China Journal of Chinese Materia Medica
基金
国家中医药管理局中医药行业科研专项(200807038)
关键词
黄芩苷
绿原酸
血药浓度
药物动力学
家兔
baicalin
chlorogenic acid
plasma concentration
pharmacokinetics
rabbits
