摘要
目的研究低温状态下腹部开放伤海水浸泡后实验动物的生存时间以及早期复温措施的效果。方法将40只腹部开放伤模型兔随机分为5组,分别在19℃海水中浸泡至肛温23、24、25、26、27℃后打捞出水,置于22℃自然条件下,观察其生存时间。将30只腹部开放伤模型兔海水浸泡至肛温25℃打捞出水,随机分为3组:对照组在23℃条件下自然复温;救治1组控出腹腔海水,擦干皮肤置于电热毯内复温;救治2组以40℃生理盐水1000ml灌洗腹腔后控出腹腔积水,擦干皮肤置于电热毯内复温。观察各组生存时间的差异。结果出水温度23、24、25、26、27℃组动物的自然存活时间依次为0.58±0.11、2.40±1.52、10.76±4.97、23.50±5.35、41.60±3.13h,组间比较差异有统计学意义(P<0.01)。救治1组、救治2组生存率均明显低于对照组(P<0.01),而救治1组与救治2组生存率无统计学差异(P>0.05)。结论对海水浸泡腹部开放伤进行早期复温可有效延长实验动物生存率,为后续治疗创造机会。
Objective To study the survival time of animals with open abdominal wound and seawater immersion with hypothermia, and the effects of early rewarming measures.Methods Forty rabbits with open abdominal wound were randomly divided into 5groups（8 each）,and then immersed in 19℃seawater till the rectal temperature of the animals reaching 23,24,25,26and 27℃,respectively.The rabbits were then scooped up and placed under natural conditions of 22℃,and the survival time of different groups was observed.Another batch of 30rabbits with open abdominal wound were immersed into seawater of 21℃and scooped up when the rectal temperature reaching 25℃,and then randomly divided into 3groups（10each）：rabbits of control group were placed under natural conditions of 23℃;amimals of treatment group 1were turned over to empty the seawater from the abdominal cavity,dried,covered with dry towel and then placed into electric blankets;animals of treatment group 2were douched with 1000ml of 40℃saline,and then turned to empty the abdominal cavity, dried,covered with dry towel and placed under electric blankets.The survival time of each group was observed.Results The survival time of rabbits with rectal temperature of 23,24,25,26and 27℃ when scooped out of seawater was 0.58±0.11h,2.40±1.52h,10.76± 4.97h,23.50±5.35hand 41.60±3.13h,respectively,showing significant difference among the groups（P〈0.01）.The survival time of treatment group 1and treatment group 2was shorter than that of control group（P〈0.01）,but no significant difference was found between these two group（P〉0.05）.Conclusion Early rewarming may effectively prolong the survival time of seawater-immersed experimental animals with open abdominal wound,and further treatment can therefore be given.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2010年第12期1496-1498,共3页
Medical Journal of Chinese People's Liberation Army
基金
全军"十一五"重大专项课题(06D004)
关键词
低温
浸渍
海水
腹部损伤
复温
hypothermia； immersion； seawater； abdominal injuries； rewarming
