摘要
烟曲霉是最常见的空气播散性真菌病原体,在免疫受损患者,烟曲霉常引起侵袭性曲霉病(invasive aspergillo-sis,IA)。与大多数的原发性病原菌不同,烟曲霉没有在宿主相关组织生长的毒力特征,研究表明烟曲霉的毒力特性是在自然界中抵制不利因素而产生的。这些特性不仅增加了其在生态环境中的总体竞争力,而且促进了它在人类宿主中的存活和生长。尽管许多与这些毒力特性相关的基因不符合经典毒力因子的定义,但对IA的致病机制仍很重要,主要包括与耐热生长、细胞壁屏障、分泌毒性产物、对环境的感知及信号传导、获取营养等方面有关的因子。
Aspergillus fumigatus is one of the most common airborne fungal pathogens causing invasive aspergillosis in immunocompromised patients.Unlike most primary pathogens,which possess virulence traits that developed in association with a host organism,evidence suggests that the virulence of Aspergillus fumigatus has evolved from the resistance to the adverse factors encountered in nature.These features enhance the overall competitiveness of the organism in its environmental niche but are also thought to promote its growth and survival in a human host.Although many of the genes responsible for these characteristics do not fit into the classical definition of a virulence factor,they are important to the pathogenesis of aspergillosis,including the genes involved in thermotolerant growth,cell wall barrier,damaging products secretion,signaling and responding to environment,nutritional requirements,and so on.
出处
《医学研究生学报》
CAS
2010年第11期1209-1212,共4页
Journal of Medical Postgraduates
基金
江苏省博士后基金(0802032c)
关键词
侵袭性曲霉病
毒力基因
毒力分子
Invasive aspergillosis
Virulence gene
Virulence molecule
