摘要
目的 观察慢性酒精依赖（CAD）患者双侧海马体积变化及1H-MRS表现,为CAD患者的临床诊断起量化指导作用.方法 选取临床确诊的16例CAD患者（CAD组）和18名正常志愿者（对照组）分别进行MR常规扫描、三维快速扰相位梯度回波（3D-FSPGR）扫描以及海马1H-MRS扫描,分别测量两组受试者海马体积,并对CAD组及对照组的双侧海马标准化体积进行比较;测量两组双侧海马头部的N-乙酰天冬氨酸（NAA）、胆碱（Cho）、肌醇（ml）以及肌酸（Cr）,对Cho/Cr、Cho/NAA、NAA/Cr及mI/Cr比值进行比较.两组间海马体积及双侧海马头部1H-MRS监测值的比较采用t检验.结果 CAD组左、右侧海马体积分别为1.881±0.292、2.139±0.328,对照组分别为2.106±0.245、2.267-±0.271,CAD组及对照组内左、右侧海马体积差异无统计学意义（t值分别为0.232、0.147,P值均＞0.05）;两组间左、右侧海马体积差异也无统计学意义（t值分别为0.424、0.131,P值均＞0.05）.CAD组的右侧海马头部Cho/Cr、NAA/Cr分别为1.225±0.210、1.145±0.034,对照组分别为1.429±0.286、1. 612±0.444,两组间差异有统计学意义（t值分别为0.321、0.408,P值均＜0.05）.两组间海马头部右侧Cho/NAA、mI/Cr及左侧Cho/Cr、Cho/NAA、NAA/Cr及mI/Cr差异均无统计学意义.结论 CAD患者尚未出现脑组织形态学改变之前,1H-MRS的表现具有为临床早期诊断提供客观量化依据的潜能.
Objective To observe the changes of the bilateral hippocampal volume （BHV） and 1H-MRS appearance of chronic alcohol dependent （CAD） patients and to provide quantitative information for the clinical diagnosis of CAD. Methods The conventional MR imaging including three-dimensional fast spoiled gradient recalled echo （3D-FSPGR） and 1H-MRS were performed on 16 patients with CAD （CAD group）and 18 cases of volunteer （ control group）. The BHV were measured in both groups and the standardized BHV in CAD group and control group were compared. 1H-MRS metabolites including N-acetylaspartate （NAA）, Choline compounds （Cho）, Creatine （Cr）, and myoinositol （mI） of the bilateral cephalic hippocampus were acquired. The ratios of Cho/Cr, Cho/NAA, NAA/Cr and mI/Cr within the bilateral cephalic hippocampus of the two groups were compared. The t test was used to compare the BHV and the ratios of 1H-MRS in the bilateral cephalic hippocampus between the two groups. Results In CAD group,the left and the right hippocampal volume were 1. 881 ±0. 292, 2. 139 ±0. 328 respectively while they were 2. 106 ±0. 245 and 2. 267 ±0. 271 respectively in the control group. The BHV had no significant difference between the left and the right in either the CAD group or the control group （t =0. 232, 0. 147 respectively,P ＞ 0. 05）. The BHV had no significant difference between the CAD group and control group（t = 0. 424,0. 131 respectively ,P ＞0. 05 ）. The Cho/Cr and NAA/Cr in the right cephalic hippocampus of the CAD group were 1. 225 ±0. 210 and 1. 145 ±0. 034 respectively, while they were 1. 429 ±0. 286, 1. 612 ±0. 444 respectively in the control group（t =0. 321,0. 408 ,P ＜0. 05 ）. The Cho/NAA, mI/Cr in the right cephalic hippocampus and the Cho/Cr, Cho/NAA, NAA/Cr and mI/Cr in the left cephalic hippocampus between the two groups had no statistically significant difference. Conclusion 1H-MRS could potentially provide early diagnostic evidence for CAD patients before the onset of cerebral mor
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2010年第12期1276-1279,共4页
Chinese Journal of Radiology
基金
湖北省科技攻关项目（2007AA402C65）
湖北省卫生厅科研基金资助项目（JX3B19）
关键词
海马
行为
成瘾
酒精中毒
磁共振成像
磁共振波谱学
Hippocampus
Behavior,addictive
Alcoholism
Magnetic resonance imaging
Magnetic resonance spectroscopy
