摘要
糖尿病并发症的发病机制涉及多个因素，与遗传易感性、糖代谢紊乱、氧化应激等密切相关，但具体机制尚未明确。近年研究发现其发病过程与低氧密切相关，而低氧诱导因子-1（HIF-1）是缺氧时重要的转录调控因子，可通过对下游基因的转录调控参与血管发生、能量代谢、细胞凋亡等病理生理过程，以适应低氧环境。探讨HIF-1结构和功能的调节及其在糖尿病并发症中的作用，研究如何维持HIF-1的适度表达，为防治糖尿病并发症提供了新的思路。
The pathogenesis of diabetic complications is related to many factors, including genetic susceptibility,glycometabolism disorder,oxidative stress and so on. But the pathogenesis is not so clear. Recent researches show that diabetic complications are closely related to hypoxia,and hypoxia-inducible factor-I （HIF-I） is an important factor for transcriptional control. HIF-1 participates in angiogenesis,energy metabolism,apoptosis and so on,through controlling the downstream transcription of genes in order to adapt hypoxia enviromnent. Discussing the structure,function adjustment and effect in diabetic complication of HIF-1 ,studying how to maintain moderate expression of HIF-I ,ean provide a new method for prevention of diabetic complications.
出处
《国际内分泌代谢杂志》
2010年第6期411-413,417,共4页
International Journal of Endocrinology and Metabolism
基金
基金项目：国家自然科学基金资助项目（30670980）
关键词
糖尿病并发症
低氧诱导因子-1
氧化应激
Diabetic complication
Hypoxia-inducible factor-I
Oxidative stress
