摘要
目的研究血清尿酸（SUA）水平与非酒精性脂肪肝（NAFL）发病的关系。方法选入246例NAFL患者为NAFL组和年龄匹配的门诊健康体检排除脂肪肝者246例为无NAFL组,比较两组SUA水平;将入选者SUA水平四分位处理,分析各段SUA水平和NAFL发病率的关系;用Logistic回归分析NAFL的危险因素。结果 NAFL组SUA水平增高（P〈0.01）,且随尿酸水平增高,受试者的NAFL患病率也成倍增长（Q1~Q4依次为11.91%、27.74%、47.67%、85.04%）,Logistic回归分析证明高尿酸血症是NAFL的独立危险因素（OR：1.579;95%C I：1.080~1.628,P〈0.01）。结论高SUA水平与NAFL发病关系密切,SUA可能是NAFL发病机制研究和临床防治新的靶点。
Objective To investigate the correlation between serum uric acid（SUA）level and the prevalence of nonalcoholic fatty liver.Methods 246 patients with nonalcoholic fatty liver（NAFL）were selected as NAFL group,while 246 controls ruled out NAFL by health examination in our outpatient department were selected as non-NAFL group.The blood samples of all subjects were collected for the comparison of SUA level between the two groups.In addition,their SUA levels were divided into four ranges（Q1：male ≤ 334 μmol/L,female ≤ 272 μmol/L;Q2：male 335-381 μmol/L,female 273-311 μmol/L;Q3：male 382-425 μmol/L,female 312-356 μmol/L;Q4：male ≥ 426 μmol/L,female ≥357 μmol/L）,and the correlation between each range of SUV level and the prevalence of NAFL were analyzed.Meanwhile,logistic regression analysis was applied to study the risk factors of NAFL.Results SUA level in NAFL group was significantly higher than that in non-NAFL group（P0.01）.The prevalence of NAFL almost doubled with the increase of SUA level.From Q1 to Q4,it was 11.91%,27.74%,47.67% and 85.04% in turn.Logistic regression analysis showed that hyperuricemia was an independent risk factor of NAFL（OR：1.579;95% CI：1.080-1.628,P0.01）.Conclusion High SUA level appears to be significantly associated with the onset of NAFL,and SUA may be a novel target for the researches on the pathogenesis,prevention and treatment of this disease.
出处
《西南国防医药》
CAS
2010年第12期1295-1297,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
尿酸
非酒精性脂肪肝
相关性
serum uric acid
nonalcoholic fatty liver
correlation
