摘要
以含量81%的曲克芦丁为原料,采用优先结晶法纯化曲克芦丁。利用正交实验研究了溶剂种类,静置时间和析晶温度对纯化结果的影响。实验说明,150 g曲克芦丁粗品,在高于65℃的条件下,溶解到500 mL体积比为27∶1的甲醇与异丙醇的混合溶剂中,撒入三羟乙基芦丁晶种后降温到20~25℃,静置3 h后抽滤晶体,曲克芦丁的含量提高到95%以上,收率不低于75%。
Taking 81% troxerutin as starting material,troxerutin was purified by preferential crystallization.The effects of different solvents,standing time and crystallization temperature on the purity of the product was investigated by orthogonal experiment.The results showed that 150 g crude product was dissolved in 500 L mixed solvent which was composed by 27 volume methanol and 1 volume isopropanol above 65 ℃,and then the temperature was decreased to 20~25 ℃ after scattering troxerutin crystal,and finally more than 95% troxerutin crystal was obtained after standing 3 h,and the yield of the product was more than 75%.
出处
《应用化工》
CAS
CSCD
2010年第11期1632-1634,共3页
Applied Chemical Industry
基金
河南省科技攻关资助项目(92102210121)
关键词
曲克芦丁
优先结晶法
纯化
troxerutin
preferential crystallization
purification
