摘要
目的：观察清肾汤治疗慢性肾功能衰竭（ＣＲＦ）急剧加重湿热证的疗效及对急性恶化肾功能的逆转作用。方法：９０例ＣＲＦ患者随机分为治疗组６０例，对照组３０例。２组患者均用抗感染、纠正代谢性酸中毒及电解质紊乱的西药及中药保留灌肠等常规治疗方法，治疗组加用清肾汤。结果：治疗组总有效率７６．７％，对照组为５０．０％（Ｐ＜０．０５）。治疗组治疗后临床表现积分值〔（２０．４７±２．６８）分比（１１．２６±３．８７）分〕及血肌酐水平〔（５９７．６５±２１２．６３）μｍｏｌ／Ｌ比（３２９．５３±１６７．３１）μｍｏｌ／Ｌ〕均明显下降（Ｐ均＜０．０１），对照组则无明显改善，分别为（２０．６３±１．９９）分比（１８．５２±４．１３）分，（５１２．１７±２９３．４８）μｍｏｌ／Ｌ比（４２４．６６±２０２．７６）μｍｏｌ／Ｌ（Ｐ均＞０．０５）。治疗组急性恶化肾功能逆转率为４３．３％，高于对照组１６．７％（Ｐ＜０．０５）。结论：清肾汤可以明显改善ＣＲＦ急剧加重湿热证的临床表现，降低血肌酐水平，对急性恶化的肾功能有一定的逆转作用。
Objective:To observe the curative efficacy of Qingshen Decoction (QSD,清肾汤) for sharp deterioration dampheat syndrome (DHS) of chronic renal failure (CRF) and the reverse actions on acutely deteriorated renal functions.Methods:90 cases were randomly divided into treatment group ( n =60) and control group ( n =30).Both two groups were treated with conventionally therapeutic methods of western medicine and tradlitional Chinese medicine(TCM),including stored enema of TCM,antiinfections,correcting metabolic acidosis and electrolyte disturbances.Simultaneously the QSD was added into treatment group.Results:The total effective rate was 76 7% in treatment group but 50 0% in control group ( P <0 05).After therapy the scores of clinical presentations 20 47±2 68 vs.11 26±3 87 and the levels of serum creatinine SCr,(597 65±212 63)μmol/L vs. (329 53±167 31)μmol/L were significantly depressed in treatment group (all P <0 01),meanwhile there were not significant improvements 20 63±1 99 vs.18 52±4 13 and (512 17±293 48)μmol/L vs.(424 66±202 76)μmol/L respectively in control group (all P >0 05).The reversed rate of acutely deteriorated renal functins (43 3%) in treatment group was significantly higher than that (16 7%) in control group ( P <0 05).Conclusions:QSD is able to improve the clinical presentations of sharp deterioration DHS of CRF markedly,depress the levels of SCr,and possess certain reverse actions on acutely deteriorative renal functions.
基金
安徽省教委1998年度科研计划项目
关键词
湿热证
肾功能衰竭
慢性
清肾汤
dampheat syndrome\ \ sharp deterioration\ \ chronic renal failure \ Qingshen Decoction scores of clinical presentations\ \ serum creatinine
