摘要
目的探讨血管紧张素转化酶(ACE)基因多态性与运动耐力的相关性。方法以多聚酶链反应(PCR)方法检测68例长跑运动员以及60例年龄、性别相匹配的健康对照者的ACE基因型,紫外线吸收法测定ACE活性,放射免疫法检测血浆血管紧张素Ⅱ(AngⅡ)浓度。结果运动员组II基因型频率为0.529,I等位基因频率为0.721,显著高于对照组(分别为0.333和0.575),差异有显著性(χ2=4.732、7.316,P<0.05)。运动员组DD型ACE活性和血浆AngⅡ浓度较II型显著升高,差异有显著性(F=3.93、5.15,q=2.557、5.501,P<0.05)。结论优秀运动员运动耐力可能与ACE基因I等位基因相关,ACE基因II型运动员可能有更好的训练敏感性。
Objective To investigate the relationship between angiotensin-converting enzyme （ACE） gene polymorphism and physical endurance. Methods Using polymerase chain reaction method, ACE genotype in 68 long-distance running athletes, and 68 healthy controls with age-sex matched was detected. ACE activity was ditermined by ultraviolet absorbtion method, and an- giotensin Ⅱ （Ang Ⅱ ） levels in plasma by radioimmunity. Results The frequency of genotypeⅡ in athlete group was 0. 529, and that of allele I was 0. 721, being significantly higher than that in the control, which were 0, 333 and 0. 575, respectively （Xz= 4. 732,7. 316;P〈0.05）. The levels of DD genotype ACE activity and plasma Ang Ⅱ in athlets were higher than that in genotype II, the differences being significant （F=3.93,5.15;q=2. 557,5. 501 ;P〈0.05）. Conclusion Physical endurance of outstanding athletes may have an association with ACE gene I alleles and athletes with ACE gene Ⅱ genotype may have a preferable training sensitivity.
出处
《青岛大学医学院学报》
CAS
2010年第6期482-484,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
血管紧张素转化酶
基因
多态现象
遗传
身体耐力
angiotensin-converting enzyme
gene
polymorphism, genetic
physical endurance
