摘要
目的:评价奎尼丁与胺碘酮治疗心房纤颤(房颤)的临床特点及对心肌复极的影响。方法:回顾性分析36例胺碘酮与17例奎尼丁治疗房颤的转复率。短期防止复发的维持率及致恶性心律失常发生率,同时观察其对QT间期,QT离散度的影响,并与阵发性房颤和健康对照组比较。结果:奎尼丁组药物复律与胺碘酮组无差异,短期(10d)防止复发率相近,但奎尼丁组2例致命性心律失常而胺碘酮无1例发生;阵发性房颤组与健康组QT间期和QT离散度无差异,与前两对照组比,奎尼丁和胺碘酮均延长QT间期和QTD,但奎尼丁比胺碘酮影响更大。结论:奎尼丁和胺碘酮均可有效治疗房颤,但胺碘酮相对安全;两者均延缓心肌复极并使复极离散,尤以奎尼丁为著。
Objective:To evaluate the clinical response of quinidine and amiodarone and their effects on the myocardial repolarization in patients with fibrillation.Methods:17 cases treated treated with quinidine and 36 cases treated with amiodarone are retrospectively analysed in their rates of conversion,recurrence,and proarrhythmia of atrial fibrillation.At the same time,their effects on the QT internal and QT dispersion are compared.They are also compared with those of paroximal atrial fibrillation and health group.Results:Lethal arrhythmia occurred in two of the quinidine group but in none of the amiodarone group,despite no differece in pharmacologic conversion and reocurrence of atrial fibrillation between two groups;No difference in QT internal and QT dispersion occurred between paroxymal atrial fibrillation and health group,however,compared with the previous two groups,these parameter were found both significantly increased in quinidine and amiodarone groups,especially in quinidine group,in which all indices but QT increase greater than amiodarone group.Conclusion:Quinidine and amiodarone both can control atrial fibrillation,but the later is safer.They both prolong and diffuse myocardial repolarization,but the former is more obvious.
出处
《中国现代医学杂志》
CAS
CSCD
1999年第4期9-10,共2页
China Journal of Modern Medicine
关键词
奎尼丁
胺碘酮
心房纤颤
心肌复极
Quinidine
Amiodarone
Atrial fibrillation
QT dispersion