摘要
目的:评价坎地沙坦在降压同时对大动脉弹性的改善效果。方法:选择48例高血压患者,随机分成坎地沙坦治疗组和氢氯噻嗪对照组,每组各24例,分别给予坎地沙坦(8mg.d-1)及氢氯噻嗪(25mg.d-1)行降压治疗,如果血压下降不理想则两组均加用非洛地平(5mg.d-1),在治疗前及治疗20周以后分别检测血压及颈-股动脉脉搏波传导速度(C-FPWV)值。结果:在两组患者血压下降水平无明显差异的情况下(P>0.05),坎地沙坦组治疗后的C-FPWV值较氢氯噻嗪组有明显下降(P<0.05)。结论:坎地沙坦能明显的改善大动脉弹性,这种改善作用与降压本身及降压之外的因素均有关。
Objective： To evaluate the effect of candesartan on large arterial elasticity of patients with essential hypertension.Methods： 48 patients with essential hypertension were randomly divided into two groups and respectively receive treatment with Candesartan（8mg ·d^-1） and Hydrochlorothiazide（25mg·d^-1）for 20 weeks.If the patients cannot attain a satisfactory drop in blood pressure,they would receive the combined treatment with Felodipine（5mg·d^-1）.All patients were measured the blood pressure and C-FPWV before and after treatment.Results： Under the same drop in blood pressure condition（P〉0.05）,The C-FPWV was remarkably decreased in candesartan group（P〈0.05）.Conclusion：Candesartan can significantly decrease the C-FPWV of patients with hypertension,Which is relevant to blood pressure reduction and other factors.
出处
《数理医药学杂志》
2010年第6期701-703,共3页
Journal of Mathematical Medicine
