摘要
目的探讨急性白血病(AL)患者医院感染(NI)的特点及影响因素,为有效预防控制NI提供依据。方法对147例AL患者的NI情况进行回顾性分析,对选取的12个危险因素进行单因素Logistic回归分析,筛选出的危险因素纳入非条件Logistic回归模型进行多元分析。结果 NI发生率47.62%;感染部位主要为呼吸道、肛门、血液为主;致病菌以G-杆菌和G+球菌为主。单因素分析筛选出住院天数、AL类型、化疗强度、白细胞计数、中性粒细胞绝对数、血红蛋白数、血清白蛋白数、抗生素种类、广谱抗生素使用天数等为AL患者发生NI的危险因素;多因素回归分析结果显示,广谱抗生素累计使用天数、中性粒细胞数、血清白蛋白数、化疗强度是NI的主要危险因素。结论针对上述独主要危险因素采取切实可行的预防措施,可减少AL患者NI的发生。
Objective To investigate nosocomial infection risk factors and characteristics in acute leukemia and provide a basis for prevention of that infection.Methods A retrospective review of the medical records of 147 patients with acute leukemia（AL） was performed.Twelve factors were chose for univariate logistic regression analysis and multivariate logistic regression analysis.Results The incidence of nosocomial infection was 47.62%.The main infection sites were the respiratory tract,anus,and blood.Gram-negative bacteria and G-positive cocci were the main pathogenic bacteria.Univariate logistic regression analysis showed that length of hospitalization,form of AL,intensity of chemotherapy,leucocyte count,absolute neutrophil count in peripheral blood,hemoglobin count,serum albumin level,category of antibiotic,and duration broad-spectrum antibiotics were used were independent risk factors for nosocomial infection.Multivariate logistic regression analysis showed that the duration broad-spectrum antibiotics were used,absolute neutrophil count in peripheral blood,serum albumin level,and intensity of chemotherapy were major risk factors.Conclusion The incidence of NI in patients with AL can be reduced with effective prevention of risk factors.
出处
《中国病原生物学杂志》
CSCD
2010年第11期858-860,I0003,共4页
Journal of Pathogen Biology
