摘要
为探讨同基因ＳＣＴ中加用ＣｓＡ诱导同基因ＧＶＨＤ的效果，本研究在输注造血干细胞的０天始予ＣｓＡ１～２ｍｇ·ｋｇ－１·ｄ－１加入生理盐水静滴，每天持续４ｈ以上，每疗程２８ｄ，所输血细胞均经照射２５００ｒａｄ以上。选献血员１４名做为正常组。未用ＣｓＡ的恶性淋巴瘤患者ＢＭＴ５例、ＰＢＳＣＴ９例做为对照组。结果发现成功诱导出ＧＶＨＤ者１３例，占６１８％，主要临床表现为：流泪、流涎、流清涕、关节肿痛、腹泻、皮肤斑丘疹；皮疹活检病理检查证实为：Ⅰ～Ⅱ度ＧＶＨＤ。停ＣｓＡ后２ｄ，Ｔ３、Ｔ４及Ｔ４／Ｔ８比例明显增高；目前随访１０７～６３４ｄ，复发２例，复发率为１５４％，较对照组的复发率（５７１％）明显为低（Ｐ＜００５）。说明同基因ＳＣＴ中加用ＣｓＡ，能成功诱导同基因ＧＶＨＤ，有望减低复发率。
To explore inducing effect of additional administratoin cyclosporin A(CsA) on graft-versus-host diseases (GVHD) in syngenic hematopoietic stem cell transplantation(SCT),CsA (1～2mg·kg -1 ·d -1 ) was administered by intravenous drip since the day of SCT,lasting for 28 days.Blood was irradiated above 2500rads before transfusion.The results showed that the GVHD was induced successfully in 13 case,accounting for 61 8%.Their main clinic signs included arthralgia,diarrhea,dermatic maculpapule and stuffy nose.GVHD Ⅰ or Ⅱ degree was affirmed through pathologocal examination.T 3,T 4 and T 4/T 8 rose sinificantly 2 days after stopping administration of CsA.The patients were followed up for 107～634 days.There was recurrence of 2 cases, the recurrent rate of the experimental group (15 4%) was obviously lower than that in control group(57 1%), P <0 05 It suggests that adding CsA to SCT could induce GVHD succssfully and reduce recurrent rate.
出处
《中国医师杂志》
CAS
1999年第3期11-12,共2页
Journal of Chinese Physician
