摘要
生物技术的发展使人们意识到生物大分子物质在疾病治疗中的重要作用,如DNA,RNA,肽,蛋白质等。但是,这些生物大分子的治疗效果在很大程度上取决于它们穿过细胞膜的效率。因此,人们迫切需要找到一种可以跨越细胞膜,直接将治疗性生物大分子物质运输到细胞内相应位置的手段。在过去几十年,人们发现一种小于30个氨基酸的短肽,能够将与之相连的生物分子在体内或体外的环境下带入细胞,称为细胞穿透肽(cell penetrating peptides,CPPs)。本文主要讨论CPPs跨膜转运体系的分类和机制,以及它在肿瘤治疗中的作用。
Recent advances in biotechnology give much importance to the various therapeutic biomacromolecules,such as DNA,RNA,peptides,proteins.However,their therapeutic efficiency lies greatly on the ability of crossing cell membrane barrier.Therefore,significant effort is being made to develop agents which can overcome this barrier and directly deliver therapeutic molecules into cellular compartment.Over the past decades,a promising short oligopeptides（fewer than 30 residues）,known as cell penetrating peptides（CPPs）,has made it possible to transduce biological molecules into living cells in vitro and in vivo by conjugating CPPs to desired molecules.Here,we will give an extensive review on the classification and mechanism of CPPs,with particular focus on their application in cancer therapy.
出处
《现代肿瘤医学》
CAS
2010年第12期2497-2500,共4页
Journal of Modern Oncology
关键词
细胞穿透肽
肿瘤
跨膜转运机制
cell penetrating peptides
cancer
mechanism of membrane translocation
