摘要
对１９６２ ～１９９８ 年间分离保存的３２５ 株鸡白痢沙门氏菌进行了药物敏感性测定。结果表明， 随着时间的推移， 菌株对１６ 种抗菌药物的耐药性呈现不同程度的上升趋势， 其中对氨苄青霉素， 复方磺胺， 甲氧苄胺嘧啶，链霉素， 四环素， 壮观霉素的耐药率明显上升。菌株多重耐药性的上升趋势显著， ６０ 年代菌株几乎没有多重耐药性， ７０ 年代以四耐、五耐菌株居多， ８０ 年代则以五耐、六耐、七耐菌株占绝大多数， 而９０ 年代七耐以上菌株的比率却近９０ ％ 。菌株耐药谱迅速增宽， 并对常用抗生素广谱耐药。因此， 建立鸡白痢沙门氏菌耐药性监测体系， 并积极寻求消除耐药质粒的方法， 是当前防治鸡白痢急待解决的课题之一。
strains of Salmonella Pullorum isolated from 1962 to 1998 were studied for antimicrobial susceptibility testing in this report The rates of these strains resist to antibiotic showed an increasing tendency,especially to Ampicillin,Sulfamethoxazole/Trimethoprim,Trimethoprim,Streptomycin,Tetracycline,Spectinomycin There was also a significantly increasing tendency of these strains’multi resistance,For example,the strains isolated from 1960s'hardly show multi resistance,but the majority of strains from 1970s'have the capacity to resist four or five types antibiotic,the strains from 1980s' have the capacity to resist five,six or seven types antibiotic,and the percentage of the strains which can resist seven types or even more in the 1990s’strains was almost up to 90% Therefore ,establishing surveillance system for drug resistance of Salmonella Pullorum and searching for methods curing R plasmids are an urgent problem of prevention and curing pullorum diseases at present
出处
《中国预防兽医学报》
CAS
CSCD
1999年第4期305-307,共3页
Chinese Journal of Preventive Veterinary Medicine
基金
农业部九.五重点课题
江苏省高校青蓝工程基金
关键词
鸡白痢沙门氏菌
耐药性
Salmonella Pullorum
drug resistance
changing tendency
