摘要
目的:探讨高效液相色谱技术在儿童血红蛋白(Hb)病检查的意义,并对5356例检测结果进行分析。方法:采集5356例广东地区儿童EDTA-K2抗凝血2ml,采用HPLC方法测定各血红蛋白组分含量。结果:在5356例儿童中,检出血红蛋白病977例(18.24%),其中检出β地中海贫血673例(12.57%),α地中海贫血283例(5.28%),其中包括21例CS型HbH病(0.39%),α复合β地中海贫血8例(0.15%),HbE病8例(0.15%),HbQ病5例(0.09%)。结论:广东地区儿童血红蛋白病的发生率高,应用HPLC技术加强对儿童血红蛋白(Hb)病进行筛查,早发现,早预防,指导合理婚配,对优生优育提高人口素质具有重要意义。
Objective：To investigate high perfomance liquid chromatography（HPLC） for children hemoglobin（Hb）disease,and5356 cases of test results for analysis.Method：2ml EDTA-K2 anti-coagulated blood samples were collected from 5356 Guang Dong children.The precentages of homoglobin fractions were detectede by HPLC.Results：977 patients with Hb disease were delected out from the 5356 cases（18.24 %）,of the 977 cases,β-thalassemia 673 cases（12.57 %）.α-thalassemia 283 cases（5.28 %）,in these cases including 21 cases of Hbcs/HbH Disease（0.39 %）,α/β-thalassemia 8 cases（0.15 %）.HbE 8cases（0.15 %）,HbQ 5 cases（0.09 %）.Conclusion：Guangdong it is the area with high rise of children Hb disease,It is recommended that more attention should be paid to detect children Hb disease by HPLC screening,early discovery,early prevention,guidance reasonable marriages,which plays great role in improving population quality.
出处
《现代生物医学进展》
CAS
2010年第21期4122-4124,4159,共4页
Progress in Modern Biomedicine
