摘要
目的探讨联合补充维生素C和E是否可以降低妊娠妇女先兆子的发病风险。方法计算机检索电子数据库建库以来至2010年10月关于妊娠妇女联合补充维生素C和E后妊娠结局的随机对照试验研究文献。研究结局为先兆子。采用RevMan 5.0.25软件对各项纳入研究的相对危险度(RR)及其可信区间进行合并,并进行异质性分析。结果共纳入10项研究,19656例妊娠妇女(实验组9823例,安慰剂对照组9833例)。所有纳入研究、纳入的高质量研究、纳入的低质量研究的合并RR值(95%可信区间)分别为0.94(0.80～1.11,P=0.49),1.02(0.91～1.14,P=0.79)和0.40(0.15～1.10,P=0.08)。结论妊娠期间联合补充维生素C和E不能显著降低先兆子的发病风险。
Objective To evaluate whether combined supplementation of vitamin C and E in pregnant women can reduce the risk for preeclampsia.Methods Electronic databases were searched for randomized controlled trials investigating pregnancy outcomes in women following exposure to combined vitamin C and E supplementation since the establishment of the database to Oct.2010.The end-point of the study was preeclampsia.The relative risk（RR） and confidence interval（CI） for each included studies were pooled and heterogeneity analysis was performed by using RevMan 5.0.25 software.Results Totally 10 studies involving 19 656 pregnant women at risk of preeclampsia were included,with 9 823 receiving vitamin C and E and 9 833 receiving placebo.The pooled RR values for preeclampsia in all studies,the studies with high quality,and the studies with low quality were 0.94（95% CI of 0.80-1.11,P = 0.49）,1.02（95% CI of 0.91-1.14,P = 0.79）,and 0.40（95% CI of 0.15-1.10,P = 0.08）,respectively.Conclusion Combined vitamin C and E supplementation has no potential benefit in reducing the risk for preeclampsia.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2010年第11期1206-1210,共5页
Academic Journal of Second Military Medical University
