摘要
目的观察核黄素磷酸钠对放疗性口咽黏膜炎症的治疗效果。方法 82例接受首次放射治疗的头颈部恶性肿瘤患者随机分为两组:治疗组42例,放疗期间每日静滴核黄素磷酸钠10mg;对照组40例,未用核黄素磷酸钠。结果治疗组放射性口咽黏膜炎症的发生率明显低于对照组(P<0.05)。两组间骨髓抑制及肝肾功能变化差异无统计学意义。结论头颈部肿瘤患者放疗中应用核黄素磷酸钠可有效减轻口咽黏膜炎症,对骨髓抑制、肝肾功能无明显影响。
Objective To observe the efficacy of treating radiotherapy-induced stomatitis and pharyngitis with riboflavin sodium phosphate.Methods Eighty-two patients undergoing radiotherapy for malignant tumors of head and neck for the first time were divided randomly into two groups.Riboflavin sodium phosphate 10mg IV qd.was used during radiotherapy in group A（42 cases）,which was not in group B（40 cases）.Results The incidence of radiotherapy-induced stomatitis and pharyngitis was significantly lower in group A than that in group B（P0.05）.There were no significant differences in the changes of liver and renal functions and myelosuppression between two groups.Conclusion The incidence of radiotherapy-induced stomatitis and pharyngitis can be reduced effectively by simultaneous infusion of riboflavin sodium phosphate without any adverse effect on liver and renal function and myelosuppression.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第21期2497-2498,共2页
Jiangsu Medical Journal
基金
江苏省中医药局科研基金资助项目(HL07024)
关键词
核黄素磷酸钠
放射治疗
口咽黏膜炎症
Riboflavin sodium phosphate Radiotherapy Stomatitis and pharyngitis
