摘要
目的:探讨电针夹脊穴干预海洛因依赖者心理渴求的临床效应及作用机制。方法:将120例海洛因依赖者随机分为4组,每组30例。针刺1组穴取T5-T7夹脊穴、肾俞,予电针治疗;针刺2组取四肢穴位内关、神门、足三里等,予电针治疗;模拟组于足三里、三阴交行模拟电刺激;空白组不予任何干预治疗。采用心理渴求程度视觉类比量表(VAS)评定心理渴求程度变化,采用放射免疫法检测血浆β-内啡肽(β-EP)和强啡肽-A(Dyn-A)治疗前后的变化。结果:针刺1组复吸率为77.3%(17/22),低于针刺2组的88.5%(23/26)、模拟组的90.5%(19/21)和空白组的95.7%(22/23)(均P<0.05)。治疗8周、治疗10周时,针刺1组、针刺2组心理渴求程度VAS积分明显低于空白组和模拟组(均P<0.01),针刺1组低于针刺2组(P<0.05),模拟组低于空白组(P<0.05);治疗10周后,针刺1组、针刺2组血浆β-EP、Dyn-A水平均较治疗前有所上升(P<0.05,P<0.01),模拟组和空白组Dyn-A水平较治疗前下降(均P<0.01),两个针刺组较空白组和模拟组明显上升(均P<0.01),针刺1组较针刺2组上升更明显(P<0.05)。结论:电针夹脊穴可明显抑制海洛因依赖者心理渴求,降低复吸率,其机制可能与增加血浆β-EP的含量,尤其是促进血浆Dyn-A增加有关。
Objective To explore the clinical effect and mechanism of electroacupuncture at Jiaji （EX-B 2） on drug craving of heroin addicts. Methods One hundred and twenty cases of heroin addicts were randomly divided into 4 groups, 30 cases in each. In acupuncture group 1, the Jiaji（EX-B 2） points of T5 -T7 and Shenshu （BL 23） were selected with electroacupuncture; in acupuncture group 2, Neiguan （PC 6）, Shenmen （HT 7） and Zusanli （ST 36） etc. were selected with electroacupuncture; in simulation group, Zusanli （ST 36） and Sanyinjiao （SP 6） were selected with analog electrical stimulation, and in blank group no any therapy was applied. The changes of drug craving were evaluated by Visual Analogue Scale （VAS） and the changes of β-EP and Dyn-A in plasma before and after treatment were tested by radioimmunoassay. Results The relapse rate of 77.3% （17/22） in acupuncture group 1 was lower than those of 88.5% （23/26） in acupuncture group 2, 90.5% （19/21） in simulation group and 95.7% （22/23） in blank group （all P〈0.05）. At the 8th and 10th week of treatment, the VAS scores in acupuncture group 1 and 2 were much lower than those in blank group and simulation group （all P〈0.01） ; in which, it was lower in acupuncture group 1 than that in acupuncture group 2 （P〈0.05）, and lower in simulation group than that in blank group..After 10 weeks of treatment, compared with the status beSore treatment, β-EP and Dyn-A in plasma were increased in acupuncture group 1 and 2 （P〈0.05, P〈0.01）, Dyn-A was decreased in both simulation and blank groups （both P〈0.01） which was less obvious than those in both acupuncture groups （both P〈0.01） and superior in acupuncture group 1 than that in group 2 （P〈0.05）. Conclusion Electroacupuncture at Jiaji （EX-B 2-） can suppress the drug craving and reduce the relapse rate, and the mechanism may be related with the content of β-EP, especially the increase of Dyn-A in plasma.
出处
《中国针灸》
CAS
CSCD
北大核心
2010年第11期881-885,共5页
Chinese Acupuncture & Moxibustion
基金
国家自然基金资助项目:30271637
关键词
海洛因依赖
电针
夹脊穴
Β内啡肽
随机对照试验
Heroin Dependence
Electroaeupuncture
Point EX-B 2 （Jiaji）
beta-Endorphin
Randomized Controlled Trial （RCT）
