摘要
目的探讨脑弓形虫病临床病理学特征、诊断及鉴别诊断。方法对2例脑弓形虫病进行病理形态学观察及免疫组化标记,并复习相关文献。结果 2例均可见脑胶质细胞增生、慢性炎细胞浸润、巨噬细胞反应伴血管炎及血管周围炎。其中1例脑组织大片坏死,增生的胶质细胞和慢性炎细胞构成肉芽肿结构。2例病灶内均找到弓形虫病原体。免疫组化:弓形虫特异性抗体(+)。结论脑弓形虫病在后天获得性弓形虫病中较常见。病灶中确认弓形虫病原体最具诊断意义,可为临床诊断及治疗提供可靠依据。
Objective To study the pathological characteristics, diagnosis and differential diagnosis of the cerebral toxoplasmosis. Methods Pathological characteristics and immunohistochemical findings were examined in two cases of the cerebral toxoplasmosis, with review of relevant literature. Results Hyperplastic glial cells, infiltration of chronic inflammation cells, reaction of macrophages, vessel inflammation and peri-vessel inflammation were found in both cases of toxoplasmosis, while necrosis and proliferation of glial cells and chronic inflammation cells were found in 1 case. Toxoplasm were found in both cases and were positively stained by specific antibody with immunohistochemistry. Conclusion Cerebral toxoplasmosis is very common in acquired toxoplasmosis. Finding of toxoplasm in lesions can provide reliable evidence for diagnosis and treatment.
出处
《诊断病理学杂志》
CSCD
2010年第5期336-338,342,共4页
Chinese Journal of Diagnostic Pathology
关键词
弓形虫
临床病理
免疫组化
诊断
Toxoplasm
Clinicopathology
Immunohistochemistry
Diagnosis
