摘要
目的:研究抗核糖体P0蛋白抗体、抗dsDNA抗体等自身抗体在SLE及其它自身免疫性疾病诊断中的意义。方法:采用线性免疫分析法检测137例SLE患者及156例其它自身免疫性病患者(75例类风湿关节炎、39例强直性脊柱炎、27例干燥综合征、15例皮肌炎)血清中抗P0抗体、dsDNA抗体、抗SmD1抗体、抗核小体抗体、抗SSA60抗体、抗SSB抗体等抗体,比较以上抗体在SLE及其它自身免疫性疾病诊断中的意义。结果:抗P0抗体、dsDNA抗体、抗SmD1抗体、抗核小体抗体、抗SSA60抗体、抗SSB抗体等抗体诊断SLE的敏感性,分别为37.23%、52.55%、29.2%、26.28%、57.66%、49.64%、32.85%。抗P0抗体、dsDNA抗体、抗SmD1抗体、抗核小体抗体在SLE诊断有较高的特异性,分别为98.08%、98.72%、94.87%、96.15%。抗SSA60抗体、抗SSA52抗体、抗SSB抗体特异性较差,分别为48.08%、53.85%、66.03%。结论:在诊断SLE的特异性抗体中,尽可能选择多种抗体组合,使各种抗体相互补充,定能提高SLE诊断率。
Objective：Study the clinical diagnosis significance of the Anti -Ribosomal P0 Protein Antibody and the anti -dsDNA Antibody and so on in SLE and other autoimmune disease. Methods：To detect the anti- Ribosomal PO protein Antibody and and the antidsDNA antibody and the anti- StuD1 antibody and the anti - nuclear body Antibody and the auti - SSA60KD antibody and the anti -SSA52KD antibody and the anti -. SSAB antibody in the serum of 137 SLE sufferers and 156 other autoimmunologie disease sufferers by line imrounoassay. To compare the clinical diagnosis significance in the SLE sufferers and the other autoimrounologie disease sufferers. Results：The sensitivity of these antibodies to diagnose SLE were 37.23% ,52.55% ,29.2% ,26.28% ,57.66% ,49.64% ,32.85%. Conclusion： Choosing various antibody corabinations possibly in the particularity antibody to diagnose SLE can certainly raise the positive rate of SLE diag＇nosis.
出处
《医学信息（中旬刊）》
2010年第12期3461-3462,共2页
Medical Information Operations Sciences Fascicule
