摘要
目的研究含羞草总黄酮(TFM)对四氯化碳(CCl4)所致小鼠急性肝损伤的保护作用。方法用四氯化碳建立小鼠肝损伤模型,相应药物灌胃后测定小鼠血清ALT、AST的活性,血清白蛋白(Alb)含量以及总抗氧化能力(T-AOC);并测定肝匀浆丙二醛(MDA)含量和超氧化物歧化酶(SOD)的活性,同时观察肝脏组织病理学变化。结果与模型对照组相比,含羞草总黄酮(TFM)各剂量组ALT、AST和MDA含量均明显降低(P<0.05或P<0.01),Alb含量和T-AOC活性均明显增加(P<0.05或P<0.01),SOD活力明显增强(P<0.05或P<0.01)。结论含羞草总黄酮(TFM)能明显改善肝组织病理损伤程度,对四氯化碳所致小鼠急性肝损伤具有明显的保护作用。
Objective To study the protective effect of total flavonoids from Mimosa pudica L on CCl4-induced acute liver injury in mice. Methods A liver injury model was induced by administration of carbon tetrachloride （CCl4） into mice. After the administration of drug, the activities of serum alanine aminotransferase （ALT） and aspate aminotransferase （AST） were tested; the activities of serum albumin and total antioxidant capabilities （T-AOC） were mearsured, the contents of malondialdehyde （MDA） and the activity of superoxide dismutase （SOl）） in hepatical tissues in mice were also mearsured, and hepatic pathological tissue were observed. Results Compared with the model group, the contents of ALT, AST and MDA were obviously decreased （P 〈 0.05 or P 〈 0. 01）, the activities of Alb and T-AOC were obviously increased （P 〈 0.05 or P 〈 0.01）, and the SOD activity was obviously improved （ P 〈 0.05 or P 〈 0.01 ）. Conclusion By observation of pathological slices, TFM could improve hepatic pathological changes distinctly. TFM could protect the acute hepatic injury induced by CCl4 in mice.
出处
《实用临床医药杂志》
CAS
2010年第10期9-11,20,共4页
Journal of Clinical Medicine in Practice
