摘要
目的 探讨血清同型半胱氨酸（HCY）、叶酸、维生素B12水平与冠状动脉病变程度的关系.方法 将98例患者根据冠状动脉造影结果分为单支病变组（33例）、多支病变组（35例）和正常组（30例）,对3组患者血清HCY、叶酸、维生素B12进行测定.结果 病变组HCY[单支病变组（15.94±6.53）μmol/L,多支病变组（20.79±8.75）μmol/L]高于正常组（9.61±4.71）μmol/L,（P＜0.01）,差异有统计学意义,单支病变组患者血浆HCY与叶酸、维生素B12水平呈负相关（r=-0.678,r=-0.6719,P＜0.05）,多支病变组HCY与叶酸、维生素B12呈明显负相关（r=-0.7619,r=-0.7894,P＜0.01）.结论 高HCY水平与冠状动脉病变程度密切相关,叶酸及维生素B12浓度是影响血清HCY水平的重要因素.
Objective To investigate the relation among serum homocysteine （HCY）, folic acid （FA）,vitamin B12 and the extent of coronary artery lesion in patients with coronary heart disease （CHD）. Methods The study included 68 CHD patients and 30 non-CHD patients diagnosed according to the coronary angiography findings.Venous blood samples were taken in all subjects and analyzed for HCY, FA, VitB12. Results The concentration of HCY in CHD group was significantly higher than that in non-CHD control group （ P 〈0. 01 ）. HCY and FA or VitB12 were remarkably negative related（r = - 0. 678, r = - 0. 6719, P 〈 0. 05 ） in single-vessel group; while in multi-vessel group HCY and FA or VitB12 are remarkably negative related（r= -0.7619, r = -0.7894, P〈0. 01）. Conclusions The high level of HCY is closely related to the extent of coronary artery lesion. Serum FA and VitB12 play an important role in the regulation of serum HCY level.
出处
《中国医药》
2010年第12期1118-1119,共2页
China Medicine
