摘要
目的观察帕罗西汀合并利培酮治疗强迫症的疗效和不良反应。方法将符合入组条件的74名强迫症患者随机分成研究组和对照组,研究组服用帕罗西汀和利培酮,对照组单用帕罗西汀,应用Y-BOCS、HAMD、HAMA量表评定疗效,记录治疗过程中的不良反应。结果治疗后两组患者Y-BOCS、HAMD、HAMA评分均明显下降(P<0.05或0.01),Y-BOCS、HAMA在第6、8周末的评分显示两组间有明显差异(P<0.05);8周末研究组总有效率81.08%,高于对照组的总有效率59.46%(P<0.05);两组不良反应比较无差别(P>0.05)。结论帕罗西汀联合小剂量利培酮治疗强迫症疗效优于单用帕罗西汀治疗的效果,不会明显增加不良反应。
Objective To explore the efficacy and side effect of paroxetive combining with low dose risperidone in the treatment of obsessive-compulsive disorder. Methods 74 patients who met the criteria of CCMD-3 for obsessive-compulsive disorder were assigned to study group and control group, study group were given paroxetine combining risperidone, control group given paroxetine only. The effect was assessed with Y-BOCS、HAMD、HAMA at the end of 2nd、4th、6th and 8th, and noted the side effect. Results After treatment, scores of Y-BOCS、HAMD and HAMA of both groups were significantly lower than pre-treatment（P0.05 or 0.01）. There were significant differences in the scores of Y-BOCS and HAMA between two groups at the end of 6th and 8th （P0.05）. The effective rate of study group （81.08%） were higher than control group （59.46%, P0.05）. There were no significantly difference in side effect between two groups （P0.05）. Conclusion Paroxetine combining with low dose risperidone has better effect in the treatment of obsessive-compulsive disorder than paroxetine only, it has fewer side effects.
出处
《中国医药指南》
2010年第33期31-32,共2页
Guide of China Medicine
关键词
帕罗西汀
利培酮
强迫症
Paroxetine
Risperidone
Obsessive-compulsive disorder
