摘要
目的:观察大黄水煎液对慢性肾功能衰竭大鼠的影响,为其临床应用提供科学依据。方法:建立大鼠腺嘌呤慢性肾功能衰竭模型,灌胃给予大黄水煎液进行干预治疗,检测相关生理、生化学指标。结果:大黄水煎液可降低慢性肾功能衰竭大鼠血清肌酐、尿素氮水平,改善肾性贫血症状,纠正钙、磷、镁等电解质代谢紊乱,纠正酸中毒,改善机体蛋白质代谢的紊乱状态,对肾脏代偿性增生有一定的保护作用。结论:大黄水煎液可改善肾功能,能延缓慢性肾功能衰竭病情的发展,对大鼠慢性肾功能衰竭有一定的治疗作用。
Objective：To investigate the effect of rhubarb decoction on experimental chronic renal failure. Methods： The rats were modeled with chronic renal failure by adenine, treated them with rhubarb decoction orally and observe the influence. Results： Rhubarb decoction can reduce serum creatinine and urea nitrogen level, improve renal anemia symptoms, and correct electrolyte disorder of calcium, phosphorus, and mag- nesium etc. Rhubarb decoction can also correct acidosis, ameliorate the disturbance of protein metabolism in the body, had some protective effect on renal compensatory hypertrophy. Conclutions： Rhubarb decoction is effective on improve renal function, delay the development Of chronic renal disease, have therapeutic effect on rats with chronic renal failure.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2010年第5期91-94,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家中医药管理局中医药科学技术研究专项(NO.06-07JP38)
