摘要
目的：探讨水蛭防治微血管吻合术后血栓形成的作用及机理；方法：采用端端吻合法建立微小血管吻合术后家兔动物模型，治疗组以水蛭精制颗粒作抗凝剂，对照组不给药；结果：水蛭能抑制ＡＤＰ诱导的血小板聚集功能，降低血液粘滞度，调节６－ｋｅｔｏ－ＰＧＦ１α和ＴＸＢ２平衡；结论：水蛭能有效抑制吻合口血栓形成，提高远期通畅率，减少血管危象的发生。
Objective:To study antithrombotic effects of Hirudo on microvascular anastomosis in rabbits.Methods:end-to-end vascular anastomosis was applied for microvascular-Sutures.Hirudo was administered as a systemic anticoagulant in the trials.Nothing was administered in the controls.Results:Hirudo had the characteristics of inhibiting platelet aggregation induced by A.D.P;regulating balance of TXB 2/6-keto-PGF 1α and decreasing blood viscosity.Conclusion:It is effect to reduce the vascular crisis caused by thrombosis in incisions.
出处
《中国中医骨伤科》
1999年第3期1-3,共3页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
关键词
水蛭
血凝集
血栓形成
微血管
吻合口
Hirudo Microsurgery Blood coagulation Thrombosis Hemorrheology
