摘要
目的比较舍曲林与氯丙咪嗪治疗强迫症的临床疗效及不良反应。方法将60例强迫症患者随机分为舍曲林组和氯丙咪嗪组,疗程均为8周。分别于治疗前和治疗后第2、4、6、8周未采用Yale-Brown强迫量表(Y-Bocs)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效,采用副反应量表(TESS)评定不良反应。结果舍曲林组和氯丙咪嗪组治疗后,Y-Bocs、HAMD、HAMA分值均显著下降,差异无统计学意义。舍曲林不良反应发生率明显少于氯丙咪嗪。结论舍曲林治疗强迫症与氯丙咪嗪疗效相当,不良反应轻,值得推广。
Objective To compare clinical curative effect and side effect of Sertraline with that of clomipramine on obsessive - compulsive disorder （OCD）. Methods 60 cases with OCD were randomly divided into 2 groups： sertraline group and clomipramine group; the treat- ment courses of both groups lasted for 8 weeks ; the curative effects in both groups were evaluated with Yale - Brown obsessive - compulsive scale （Y -Bocs）, HAMD and HAMA at different time points： before treatment, 2 weeks, 4 weeks, 6 weeks and 8 weeks after treatment; TESS was applied in evaluating the side effect. Results The scores of Y - Bocs, HAMD and HAMA in both groups after treatment de- creased greatly with no statistical difference while the occurrence of side effect in sertraline group was much lower than that in clomipramine group. Conclusions Sertraline is of similar curative effect with clomipramine in treating OCD but has less side effect.
出处
《西南军医》
2010年第6期1049-1050,共2页
Journal of Military Surgeon in Southwest China
关键词
舍曲林
氯丙咪嗪
强迫症
sertraline clomipramine obsessive - compulsive disorder （OCD）
