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癌症相关促凋亡蛋白Par-4的信号转导途径预测研究 被引量:1

Prediction Signaling Transduction Pathways of Cancer-related Apoptosis Protein Par-4
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摘要 利用支持向量机(SVM)技术构建Par-4关联的蛋白质相互作用网络,预测出与Par-4有相互作用的蛋白质82个;这些蛋白质按照功能划分为8大类,主要包括:蛋白激酶、泛素化蛋白酶、死亡受体相关因子、与细胞周期或DNA复制相关蛋白质、调节蛋白质、与疾病相关蛋白质、具有特定结构域结合蛋白质和其他蛋白质等。结合文献挖掘和数据库检索信息,推断出了Par-4的2条可能新的信号转导途径。首次预测到Par-4与一大类泛素化蛋白有密切的关系。研究发现,Par-4与多种蛋白质具有复杂的相互作用,并且,在多个细胞凋亡途径中扮演了重要角色。 Based on the Support Vector Machine algorithm,the protein-protein interactions(PPI) networks between Par-4,the cancer-related apoptosis protein,and related proteins have been built.There are 82 proteins have been predicted interacting with Par-4.The proteins are classified into eight groups by biological functions,which include protein kinase,death receptor associate factor,ubiquitin-protein ligase,special disease associate proteins,DNA replication related proteins,special structure associate protein,regulatory protein and others.Combined with literatures mining and molecular chaperones of Par-4 searching from BOND database,two new signal transduction pathways of Par-4 have been deduced.In this paper,we first discover that Par-4 interacts with a group of ubiquitin-proteins.We find that Par-4 has complicated interactions with many proteins.Par-4 plays a major role in some apoptosis pathways.
出处 《中山大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第6期83-88,共6页 Acta Scientiarum Naturalium Universitatis Sunyatseni
基金 国家自然科学基金重点资助项目(60736028) 广东省科技计划项目重大专项资助项目(2003A3080503)
关键词 PAR-4 SVM 蛋白质相互作用 细胞凋亡 信号转导 Par-4 SVM protein-protein interactions apoptosis signal transduction
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