摘要
目的:观察沙利度胺对恶性肿瘤化疗患者生活质量的影响。方法:将57例化疗患者随机分为两组,沙利度胺组29例,对照组28例。沙利度胺组在化疗基础上加服沙利度胺,起始剂量第一周100mg/d,晚睡前顿服,如能耐受不良反应,每周增加100mg,直至目标剂量300mg/d维持,如不能耐受加量者,则维持原剂量。对照组则单用化疗。化疗均以4周为一周期,两周期后评价疗效。结果:沙利度胺组Karnofsky评分、睡眠状况、体重状况改善率分别为55.2%、69.0%、51.7%,对照组改善率分别为17.9%、14.3%、17.9%,两组比较差异有统计学意义(P<0.05)。沙利度胺组的恶心呕吐等消化道反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:沙利度胺可以改善恶性肿瘤化疗患者的生活质量。
Objective：To observe the effect of thalidomide to the quality of life of patients undergoing chemotherapy.Methods： Total of 57 patients with chemotherapy were randomly divided into two groups,the treatment group 29 cases,the control group 28 cases.Thalidomide was used in the treatment group based on the initial dose（100mg/day） in the first week before sleep.If they can tolerate side effects,a weekly increase of 100mg,until the target dose of 300mg / day,if they can not tolerate it,while maintaining the original dose.The control group accepted chemotherapy alone.Chemotherapy was four weeks as a cycle,two cycles were performed.Results： The improvement rates of Karnofsky score,sleep status,weight of the treatment group were 55.2%,69.0%,51.7%,respectively,the improvement rates of the control group were 17.9%,14.3%,17.9%.There were significant differences between two groups（P 0.05）.The treatment group of gastrointestinal reactions such as nausea and vomiting was lower than the control group,the difference was statistically significant（P0.05）.Conclusion： Thalidomide can improve the quality of life in patients with chemotherapy.
出处
《现代肿瘤医学》
CAS
2010年第11期2256-2258,共3页
Journal of Modern Oncology
