摘要
刚地弓形虫是寄生宿主广泛的细胞内寄生性原虫,人群感染相当普遍。弓形虫侵入宿主细胞后寄居于一个抗宿主细胞内涵体酸化作用和溶酶体融合作用的纳虫泡(parasitophorous vacuole)内,纳虫泡在弓形虫的寄生过程中起着非常重要的作用。本文就弓形虫纳虫泡形成的机制及其在弓形虫寄生宿主细胞过程中的作用进行综述。
Toxoplasma gondii is a ubiquitous, obligate intracellular protozoan parasite in human and animals. Chronic infection with this parasite is likely one of the most common infection in human. Following invasion of host cells T. gondii resides within membrane-bound vacuoles known as parasitophorous vacuole （PV）, which can protect the parasite from the endosomal acidification and lysosomal fusion of host cells. It plays an essential role in the whole parasitic process of T. gondii. This review summarizes the mechanism of PV formation and its function in the host cells.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2010年第5期382-386,共5页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金(No81071377)
广东省自然科学基金(No10151051501000033)
广东省医学科研基金(NoA2010356)~~
关键词
刚地弓形虫
纳虫泡
细胞内寄生
Toxoplasma gondii
Parasitophorous vacuole
Intracellular parasitization
