摘要
目的 观察佩尼聚醚砜空心纤维透析器（PES14HF）对维持性血液透析患者的有效性和安全性.方法 36例血液透析患者分别使用PES14HF和日本尼普洛株式会社生产的聚醚砜空心纤维透析器（PES-150DS）进行透析,每次3.5 h以上.以透析前后血肌酐、尿素氮和β2-微球蛋白等指标的清除及下降率进行疗效评估,以透析前后外周血血红蛋白（Hb）、白蛋白（Alb）等指标的变化进行安全性评估.结果 ES14HF组治疗前后血肌酐分别为（990.2±191.2）、（333.8±89.5）μmol/L,血尿素氮分别为（24.7±4.1）、（7.0±1.9）mmol/L,β2微球蛋白分别为（22.9±1.7）、（13.6±3.3）mmol/L,治疗前后差异均有统计学意义（P均＜0.01）.PES-150DS组治疗前后血肌酐分别为（1059.5±179.4）、（395.5±86.1）μmol/L,血尿素氮分别为（25.3±4.8）、（8.1±2.8）mmol/L,β2微球蛋白分别为（22.3±2.9）、（18.0±3.0）mmol/L,治疗前后差异均有统计学意义（P均＜0.01）;但2组间治疗前后血肌酐、尿素氮、β2微球蛋白比较,差异均无统计学意义（P均＞0.05）.2组透析后血β2微球蛋白均下降,但PES14HF组溶质下降率更明显（P=0.017）.结论 佩尼聚醚砜空心纤维透析器PES14HF在维持性血液透析患者中的应用安全、有效.
Objective To investigate the efficacy and safety of polyethersulfone highlux dialyzer for maintenance hemodialysis patients. Methods Thirty-six maintenance hemodialysis patients were randomizedresigned into two groups,polyethersulfone 14HF（PES-14HF）group and polyethersulfone 150DS（PES-150DS）group,based on a random number table. The patients from two groups received different dialyzer hemodialysis for over 3.5 hours/each time respectively. Changes of serum creatinine,urea,β2-microglobulin,hemoglobin and albumin levels were measured for determination of the efficacy and safety evaluation. Results In the comparison between before or after hemodialysis,the level of serum creatinine,urea,β2-microglobulin levels decreased significantly to（333.8 ± 89. 5）μmol/L,（7. 0 ± 1.9）mmol/L,（22. 9 ± 1.7）mmol/L from（990. 2 ± 191.2）μmol/L,（24. 7 ± 4. 1）mmol/L,（13.6 ± 3.3）mmol/L respectively in the PES1 4 HF group（P 〈 0.01）;the level of serum creatinine,urea,β2-microglobulin levels decreased significantly to（395.5 ± 86.1）μmol/L,（8. 1± 2. 8）mnol/L,（18.0 ± 3.0）mmol/L from（1059. 5 ± 179. 4）μmol/L,（25.3 ± 4. 8）mmol/L,（22. 3 ± 2. 9）mmol/L respectively in the PES-150DS group（P 〈 0. 01）. We found no significant differences in each measured index between two types of hemodialysis（P 〉 0. 05 respectively）,while the level of β2 -microglobulin levels decreased more significantly in the PES14HF group（42. 81 ± 12. 48）mg/L than PES-150DS group（24. 21 ± 13. 24）mg/L（P =0. 017）. Conclusions The efficacy and safety of the PES-14HF hollow fiber membrane hemodialyzer is equivalent to that of the PES-150DS hemodialyzer in hemodialysis for uremic patients.
出处
《中国综合临床》
2010年第11期1167-1170,共4页
Clinical Medicine of China
关键词
血液透析
聚醚砜
空心纤维透析器
肾病
Hemodialysis Polyethersulfone Highfiux dialyzer Kidney disease
