摘要
目的探讨人工肝联合CRRT(continuous renal replacement the rapy)治疗妊娠急性脂肪肝的疗效。方法 14例妊娠急性脂肪肝(acute fatty liver of pregnancy,AFLP)患者,在给予内科综合治疗的基础上,应用人工肝联合CRRT方法治疗,观察患者入科时、住院期间峰值和治疗后各项生化指标变化以及治愈率。结果所有患者人工肝联合CRRT治疗(4.0±2.8)次,经过治疗逐步消除了患者恶心、黄疸、出血及少尿等临床症状;降低患者的转氨酶、肌酐、尿素氮、凝血酶原时间和胆红素等指标,三个时间点的实验室指标差异均有统计学意义(P<0.05);14例患者中有11例存活。结论人工肝联合CRRT治疗后AFLP患者的实验室指标好转,临床症状减轻,提高了治愈率,是治疗重症AFLP患者的有效手段。
Objective To investigate the clinical effect of artificial liver combined continuous renal replacement therapy （CRRT） for the treatment of acute fatty liver of pregnancy（AFLP）. Methods On the basis of comprehensive treatment, 14 patients were treated with the artificial liver combined CRRT. The peak of the biochemical changes and the cure rate were observed when patients were enrolled during hospitalization and after treatment. Results All patients were treated with artificial liver com- bined CRRT times（ 4.0 ±2.8 ） , after the treatment, the clinical symptoms such as nausea jaundice hemorrhage and oliguria were reduced gradually,the patient＇s laboratory indicators such as aminotransferase, creatinine, urea nitrogen, prothrombin time and bilirubin were reduced, the laboratory indicators were statistically significant differences in three time points （ P 〈 0.05 ） , and 11 patients survived among 14. Conclusion The treatment with artificial liver combined CRRT can reduce the clinical symptoms, improve the cure rate and was an effective treatment of AFLP.
出处
《中华全科医学》
2010年第12期1503-1504,共2页
Chinese Journal of General Practice
关键词
妊娠急性脂肪肝
人工肝
连续肾脏替代治疗
Acute fatty liver of pregnancy
Artificial liver
Continuous renal replacement therapy
