摘要
检测３４例急性白血病（ＡＬ）患者治疗前后ｖＷＦ：Ａｇ（Ｌａｕｒｅｌｌ免疫电泳法），ＴＭ（ＥＬＩＳＡ法）和ＥＴ（ＲＩＡ法）三种血管内皮细胞损伤分子标志物的变化。结果表明，ＡＬ治疗前ｖＷＦ，ＴＭ，ＥＴ均比正常对照组显著升高，ＡＮＬＬ和ＡＬＬ组间无明显差异。化疗完全缓解后，ＴＭ和ＥＴ恢复正常，ｖＷＦ也明显降低，但仍高于正常。复发患者ｖＷＦ、ＩＴＭ、ＥＴ又均显著升高。１３例非恶性血液病与正常组无明显差别。结果提示，此３种分子标志物可作为反映ＡＬ病情和监测疗效的有用指标，其在白血病时的病理生理作用值得进一步研究。
The plasma concentrations of von Willebrand factor(vWF), thrombomodulin (TM) and endothelin (ET) as molecular markers indicating vascular endothelium injury were investigated in 34 cases of acute leukemia(AL)before and after anti- leukemia therapy, 13 cases of non-malignant hematologic diseases and 30 normal controls. The results showed that plasma levels of vWF,TM, ET were significantly increased in AL Patients and decreased after remission, and increased again re- markably if AL relapsed. But no marked difference between ANLL and ALL. In 13 cases of non-malignant hematologic diseases the Plasma levels of vWF, TM, ET had no differences comparing with the normal controls. Hence, significant de- gree of vascular endothelial cell injury existed in leukemia patients, and determination of Plasma vWF, TM, ET may be use- ful in predicting the seventy of the disease.
出处
《天津医药》
CAS
1999年第5期286-287,共2页
Tianjin Medical Journal
关键词
白血病
急性
VWF
TM
ET
leukemia, lymphocytic, acute leukemia, nonlymphocytic, acute endothelins
