摘要
目的通过对慢加急性(亚急性)肝衰竭与慢性肝衰竭患者进行中医辨证虚实属性归类,分析其与肝功能等生化指标的相关性。方法根据《肝衰竭诊疗指南》,纳入符合诊断标准的患者100例,结合症状、体征、舌脉进行中医辨证分型,分析中医证型分布情况,统计肝功能等指标,分析其与中医虚实辨证属性之间的相关性。结果①100例中,各证型出现频率由高到低依次为湿热发黄证、气虚瘀黄证、阴虚瘀黄证、阳虚瘀黄证、瘀热发黄证。②实证与虚证相比,年龄、TBIL、DBIL、ALB、ALT、AST、GGT及CHE等指标差异有统计学意义(P<0.05);HBVDNA、AFP、TP、PT、PTA、K+、Na+及Cl-等指标差异无统计学意义(P>0.05)。结论①慢加急性(亚急性)肝衰竭以实证为主,慢性肝衰竭以虚证为主。②中医虚实证型与肝功能指标存在相关性,与凝血功能、电解质、HBVDNA无明显相关。
Objective To analyze the correlation between deficiency and excess syndromes of traditional Chinese medicine （TCM） differentiating syndromes of acute-on-chronic （subacute） and chronic liver failure and biochemical parameters of liver function based on the classification of deficiency and excess attributes. Methods Totally 100 patients, who conformed to the diag- nostic criteria of the guideline to diagnosis and treatment of liver failure, were included in the study. TCM syndrome differentia- tion was made according to the signs and symptoms and tongue and pulse presentations. TCM syndrome distribution and liver function parameters were analyzed to evaluate the correlation between liver function parameters and deficiency and excess syndromes. Results The frequency of the occurrence of the TCM syndromes in 100 patients declined from heat-damp jaundice, Qideficiency jaundice, Yin-deficiency jaundice, Yang-deficiency jaundice and blood stasis-heat jaundice. Significant differences were found in age, TBIL, DBIL, ALB, ALT, AST, GGT and CHE between the deficiency and excess syndrome groups （P〈0.05）, and no significant differences were found in HBV DNA, AFP, TP, PT, PTA, K＋, Na＋ and C1- between the 2 groups （P〉0.05）. Conclusions Ex- cess syndrome is mostly prevalent in the patients with acute-on-chronic （subacute） liver failure, and deficiency syndrome in the patients with chronic liver failure. TCM deficiency and excess syndromes are correlated with liver function parameters, and not correlated with the blood coagulation function, electrolytes and HBV DNA levels.
出处
《传染病信息》
2010年第5期273-275,共3页
Infectious Disease Information
基金
国家"十一五"科技重大专项(2008ZX10005-007)
关键词
肝炎
乙型
慢性
肝功能衰竭
中医诊断学
辨证分型
hepatitis B, chronic
liver failure
diagnostics （TCM）
syndrome differentiation classification
