摘要
目的··：研究吗啡依赖后大鼠脑内吗啡含量变化。方法··：对慢性染吗啡大鼠脑组织内的吗啡进行了原位免疫组织化学研究。结果··：染毒７ｄ大鼠脑组织内未能检出吗啡，染毒１４ｄ大鼠脑组织内出现了强弱不一的免疫反应。结·论·：大鼠对吗啡依赖形成过程中，脑组织内吗啡含量增高，且吗啡的分布与μ阿片受体分布一致。
Objective:To understand the mechanism of morphine dependence.Method:Study the quantity of morphine in the brain tissues of morphine poisoned rats with immunohistochemical method.Result:Negative immunohistochemical staining occurred in the brain tissues of the rats poisoned by morphine for 7 days,but positive staining occurred in those of the rats poisoned by morphine for 14 days.Conclusion:The quantity of morphine in the brain tissues increases as rats get dependent on morphine and its distribution is accorded with opioid receptor.
出处
《中国药物依赖性杂志》
CAS
CSCD
1999年第2期107-109,共3页
Chinese Journal of Drug Dependence
关键词
吗啡依赖
免疫组化
阿片受体
morphine dependence
immunohistochemistry
opioid receptor
