摘要
7-氮杂吲哚是一类重要的杂环化合物,因与吲哚、嘌呤等在结构上的类似性,成为后两类化合物的生物电子等排体,因而引起研究者关注。许多7-氮杂吲哚衍生物具有抑制多种蛋白酶的活性,在抗组胺和抗多巴胺等方面都体现潜在的生物活性及药用价值。本文根据不同的合成策略,对近年来合成7-氮杂吲哚母核的方法以及该类化合物的抗肿瘤与抗菌等活性研究进行综述,旨在能为以7-氮杂吲哚先导化合物的结构改造及其靶点的构效关系分析提供更多的信息。
7-azaindole constitutes essential subunits in many pharmaceutical compounds. It can be considered as a bioisostere of an indole or purine moiety. With the increasing knowledge of the heterocycle, numerous compounds containing 7-azaindole core are described as biological molecules in the literature. In order to illustrate the further drug mechanisms and to find out the better lead compounds, the advances in the research on synthetic routes and the anticancer and antibacterial activities of 7 - azaindolc derivatives were reviewed.
出处
《国外医药（抗生素分册）》
CAS
2010年第5期207-218,共12页
World Notes on Antibiotics
关键词
7-氮杂吲哚
合成
抗肿瘤
抗菌
7-azaindole
synthesis
anticancer antibacterial
