摘要
目的:研究SMMHC在乳腺癌转移中的作用。方法:收集乳腺癌标本57例,其中伴有腋窝淋巴结转移的乳腺癌标本32例,不伴有腋窝淋巴结转移的25例,通过免疫组化方法检测肌球蛋白SMMHC在其中的表达。结果:伴有腋窝淋巴结转移的乳腺癌标本32例,SMMHC表达阳性率90.6%,且强阳性表达(以上)占62.5%;不伴有腋窝淋巴结转移阳性表达率80%,强阳性表达(以上)占16%,两者表达有差异。结论:伴有腋窝淋巴结转移的乳腺癌标本中SMMHC的表达明显强于不伴有腋窝淋巴结转移的乳腺癌标本,提示SMMHC的高表达与乳腺癌细胞的定向迁移以及乳腺癌转移有一定关系。
Objective： To study effection of SMMHC in breast cancer metastasis. Methods： 57 cases specimens of breast cancer were collected, 32 cases with lymph nodes metastasis, 25 cases without lymph nodes metastasis, SMMHC expression was detected by immunohistochemstry. Results： SMMHC positive rate was 90. 6% in metastasis cases, and strong positive expression（＋＋ and above） accounted for 62. 5% ;for without metastasis samples, SMMHC positive rate was 80%, and strong positive expression accounted for 16%. There was significantly difference between two kinds of breast cancer sample. Conclusion： SMMHC is significantly stronger in breast cancer metastasis samples than without metastasis sample, suggesting SMMHC is related with directional migration of breast cancer cell and breast cancer metastasis.
出处
《陕西医学杂志》
CAS
2010年第11期1445-1447,共3页
Shaanxi Medical Journal
基金
陕西省科技攻关项目(2008k09-06)
