摘要
目的：研制了环吡酮胺涂膜剂，探讨该涂膜剂的控释机理。方法：利用双室渗透扩散装置进行离体皮肤体外渗透试验，通过改变聚合物膜的厚度研究其释药机理。结果：涂膜剂中环吡酮胺以零级动力学透过皮肤，渗透速率与聚合物限速膜厚度的倒数呈良好线性关系（ｒ＝０．９９２６）。结论：环吡酮胺涂膜剂具有膜控型释药机理。
Objective:A ciclopirox olamine film was developed and its controlled release mechanism was studied.Methods:Ciclopirox olamine permeation tests in vitro through rat skin in two compartment diffusion cells were perfomed to study the penetration mechanism of ciclopirox olamine by changing thickness of polymer membranes.Results:The permeation of cicloprirox olamine in the film through the rats skin followed zeroorder kinetics and permeation rate was proportional to the reciprocal of the membrane thickness( r =0.9926).Conclusion:This film belongs to the membrane permeation controlled transdermal delivery system.
出处
《广东医学院学报》
1999年第1期8-10,共3页
Journal of Guangdong Medical College
关键词
环吡酮胺
涂膜剂
控释剂
抗真菌药
ciclopirox olamine
film
permeation rate
controlled release
