摘要
为探讨人工蛹虫草子实体(CM)在S180荷瘤小鼠体内对其免疫功能的影响,用CM 300mg·kg^(-1)和600mg·kg^(-1)的剂量连续灌胃10天,分别对有关免疫指标进行检测。结果显示,CM两个剂量组对合成抗绵羊红细胞(SRBC)抗体(血清溶血素)及其抗体形成细胞、NK细胞活性、网状内皮和单核-巨噬细胞系统的吞噬功能,以及TNF-β和IL-2的分泌水平等均有显著提高。这些表明,CM对荷瘤小鼠的多项免疫指标均有明显的增强效应,这在其扶正抗癌的作用中具有重要的意义。
To investigate effects of cordyceps militaris (CM), a kind of composition cultured from cordyceps sinensis (Berk. ) Sacc. on immune function in sarcoma S180 bearing mice in vivo. Sev-eral immunomodulatory effects of the drug were measured after per os with two dosages of 300mg/kg and 600mg/kg body weight daily for 10 days, respectively. The two doses of CM have a significant enhanced effect in comparison with controls on spleen indes, hemolysin in sera, anti-body production of B celis in the spleen, activation of phagocytosis on reticuloendothelial, mononuclear macrophage system and NK cells, and levels of TNF-β and IL-2 secretion and so on. CM evokes an antitumor immune response in the mice. It is importam for immunomodulation of cancer.
出处
《中国医药学报》
CSCD
1999年第1期25-27,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
