摘要
首次以水杨酸为原料,与4-氨基吡啶反应合成了标题化合物,实验考察了不同的反应条件对产品收率的影响,得出最佳反应条件为:7 mmol 4-氨基吡啶、8.4 mmol水杨酸酰氯、11 mL三乙胺,25℃反应18 h,产品收率为87.8%。本合成路线反应条件温和、工艺操作简便、容易控制。
2-Hydroxy-N-（pyridin-4-yl）benzamide was synthesized from salicylic acid and 4-aminopyridine.The effects of different reaction conditions on product yield were investigated.The target compound could be obtained in 87.8% yield after heating the reaction mixture（composed of 7 mmol of 4-aminopyridine,8.4 mmol of salicylyl chloride,and 11 mL of triethylamine） at 25 ℃ for 18 h.It has been proved that 2-hydroxy-N-（pyridin-4-yl）benzamide can be synthesized in high yield under the catalytic action of triethylamine.The reaction conditions suitable for this synthetic route are mild,and the process operation is simple and easily controllable.
出处
《化学试剂》
CAS
CSCD
北大核心
2010年第11期1045-1046,共2页
Chemical Reagents
