摘要
在肿瘤的表观遗传学研究中,组蛋白的乙酰化修饰对肿瘤的发生发展起重要作用。正常细胞体一旦出现核内组蛋白乙酰化与去乙酰化的失衡,即会导致正常的细胞周期与细胞代谢行为的改变而诱发肿瘤。组蛋白去乙酰化酶(histone deacetylases,HDACs)催化组蛋白的去乙酰化,维系组蛋白乙酰化与去乙酰化的平衡状态,与癌相关基因转录表达、细胞增殖分化及细胞凋亡等诸多过程密切相关。本文从组蛋白去乙酰化酶HDACs的结构分类及其与肿瘤发生发展关系两方面对HDACs做一综述。
The modification for histone acetylation is of great importance for formulation and development of tumors in the epigenetic study of tumors.The disequilibrium of histone acetylation and deacetylation may cause some changes of cell cycle and cell metabolism.Histone deacetylases（HDACs） catalyze the deacetylation of histones,and maintain the equilibrium between histone acetylation and deacetylation as well.They are related to many regulation processes containing transcription of oncogene,cell cycle,apoptosis and so on.The structure classification of HDACs and the relationship between the HDACs and the formation and advancement of tumor were reviewed in this paper.
出处
《广东药学院学报》
CAS
2010年第5期546-550,F0003,共6页
Academic Journal of Guangdong College of Pharmacy
基金
广东省科技厅立项项目(2010B031600137)
