摘要
为观察静脉输注6%羟乙基淀粉130/0.4和静脉推注呋噻米（速尿）对急性胰腺炎病例转归的影响,选择从2007年10月16日~2009年8月31日收治的患者,入院当日即给予羟乙基淀粉静脉输注（成人通常为1 000~2 000 ml）,在输注羟乙基淀粉的同时静脉推注呋噻米,力求作到出入量基本平衡;入院次日开始逐渐减少羟乙基淀粉用量。治疗135例急性胰腺炎患者（Ranson评分≥3分者54%,Balthazar CT评分≥D者61%）,胰腺局部并发症和全身并发症仅为4%和7%,胰腺手术率为4%,住院死亡率为4%。通过比较入院时和痊愈后的血细胞压积,估计入院时血容量减少平均约18.3%。结果表明：静脉输注羟乙基淀粉和静脉推注呋噻米可改善急性胰腺炎的转归。血浆外渗是急性胰腺炎的中心事件和治疗重点。
This study was conducted to observe the effects of intravenously administered 6% hydroxyethylstarch 130/0.4 solution and furosemide on the outcome of acute pancreatitis patients.Patients admitted to our center from October 16,2007 through August 31,2009 were given intravenous infusions of 6% hydroxyethylstarch 130/0.4 solution（1 000-2 000 ml administered for an adult） soon after admission.At the same time,furosemide was administered as intravenous bolus,trying to maintain a fluid balance.The dose level of hydroxyethylstarch was gradually lowered from the second day after admission.A total of 135 patients（54% of patients with a Ranson＇s score≥3 and 61% with a Balthazar CT score≥D） were treated with our protocol.Only 4% and 7% patients developed pancreatic and systemic complications respectively;only 1 patient underwent necrosectomy.The in-hospital mortality rate was 4%.It was estimated that,on the average,18.3% of blood volume was lost on admission.Our study suggest that intravenously administered 6% hydroxyethylstarch 130/0.4 solution and furosemide might be beneficial for patients with acute pancreatitis.Plasma extravasation is a central event of acute pancreatitis.The reversal of hypovolemia is crucial for the success in treatment of acute pancreatitis.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第5期1138-1141,1145,共5页
Journal of Biomedical Engineering
关键词
急性胰腺炎
羟乙基淀粉
呋噻米
Acute pancreatitis； Hydroxyethylstarch solution； Furosemide；
