摘要
目的探讨Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑的疗效和安全性。方法将210例黄褐斑患者随机分为3组,每组各70例。治疗组予Q开关Nd:YAG激光治疗联合红花逍遥片口服;对照1组单纯予Q开关Nd:YAG激光治疗;对照2组单纯口服红花逍遥片。Q开关Nd:YAG激光治疗每周1次连续10周,后2周1次再治疗6周,共16周。红花逍遥片口服2片,3次/d连续16周。分别于5,10和16周时评价临床疗效。结果 16周时治疗组有效率为90.00%,对照1组为80.00%,对照2组为41.00%,差异有统计学意义(P均<0.01);治疗组不良反应发生率为26.00%,对照1组为21.00%,对照2组为17.00%,差异无统计学意义(P>0.05)。结论 Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑比两者单独应用效果好。
Objective To explore the safety and the efficacy for treating chloasma by Q-Switched Nd：YAG Laser combining with HongHuaXiaoYaoPian. Methods Two hundred and ten patients were enrolled in treatment, control 1 and 2 group randomoly. Seventy patients of treatment group were treated once a week for 10 weeks and then two weeks a time for 6 weeks by Q-Switched Nd：YAG Laser combining with taking HongHuaXi- aoYao Plan two tables one time and three times a day for 16 weeks. Seventy patients of control 1 were treated by the Q-Switched Nd ： YAG Laser and the 70 patients of control 2 taking HongHuaXiaoYaoPian only respec- tively. The efficacy were evaluated 3 days after the treatment in 5＇h ,10th ,16~ weeks. Results The markedly effective rate of treatment group was 90.00% and that of control l and 2 group was 80.00% and 41.00% respectively. The markedly effective rate of control 1 and 2 group in 16th week was significantly lower than that of treatment group（ P 〈 0.01 ）. There was no significant difference of adverse effects rate among treat- ment group（26.00%）, control l（21.00%）and2 group（17.00%）（P〉0.05）. Conclusion The Q- Switched Nd：YAG Laser combining with HongHuaXiaoYaoPian is more effective in treatment of chloasma than the Q-Switched Nd：YAG Laser and HongHuaXiaoYaoPian respectively.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2010年第11期1019-1020,1045,共3页
The Chinese Journal of Dermatovenereology
