摘要
目的探讨a-硫辛酸联合中痘疫苗致炎兔皮提取物（恩再适）治疗化疗药物致周围神经病变的临床疗效。方法2008年1月至2010年1月诊治的246例化疗药物致周围神经病变患者，随机分为治疗组126例；对照组120例；治疗组采用a-硫辛酸联合恩再适治疗，对照组采用甲钴胺注射液和维生素B12治疗；观察两组临床疗效。结果治疗组总有效120例，总有效率95．23％，对照组总有效率99例，总有效率82．5％；两组总有效率比较，P〈0．05有显著差异性。结论a-硫辛酸联合恩再适治疗化疗药物致周围神经病变能够明显的增加感觉神经、运动神经传导速度，改善临床症状。a-硫辛酸联合恩再适治疗化疗药物致周围神经病变临床疗效确切，临床效果具有协同作用。在治疗期间无严重的不良反应，具有高度的安全性。
Objective To study a-lipoic acid and then appropriate treatment of co-ex chemotherapy induced peripheral neuropathy clinical efficacy. Methods From January 2008 to 2010 in January 246 patients treated in chemotherapy induced peripheral neuropathy were randomly divided into treatment group 126 cases; the control group of 120 cases; treatment group was a-lipoic acid treatment combined grace and then apply the control group were Methyleobalamin Vitamin B12 Injection and treatment; clinical efficacy. Results The total effective of 120 cases, total effective rate 95.23% , the efficiency of the control group was 99 cases, 82. 5% ; group total effective rate was P 〈 0. 05 significant difference. Conclusion A-lipoie acid and then appropriate treatment of co-ex peripheral neuropathy caused by chemotherapy can significantly increase the sensory nerve, motor nerve conduction velocity, improve clinical symptoms, a-lipoic acid and then appropriate treatment of eoex chemotherapy induced peripheral neuropathy is effective, the clinical effect is synergistic effect. During treatment, there was no serious adverse reactions, but with high security.
出处
《中国临床实用医学》
2010年第11期32-34,共3页
China Clinical Practical Medicine
关键词
A-硫辛酸
恩再适
化疗药物致周围神经病变
疗效分析
Alpha-lipoic acid
Analgeeine
Chemotherapy induced peripheral neuropathy
Effect Analysis
