摘要
在室温少量AlCl3催化下,芳香醛、芳香酮和芳香胺可以顺利发生Mannich反应,三组分＂一锅＂合成了7个相应的β-胺基酮衍生物,产率69%-90%,克服了当前一些方法强质子酸或昂贵催化剂的使用.所有Mannich碱的结构均经熔点、IR、1H NMR证实.
Mannich reaction of aromatic aldehydes,aromatic ketones and aromatic amines accoured with small amount of AlCl3 catalyst at room temperature.The three-component ＂one-pot＂ reaction compounds corresponding 7 β-amino ketone derivatives with a yield rate of 69% ~ 90%,which avoids the use of strong proton acids or expensive catalysts.The structure of these 7 derivatives was confirmed by melting point,IR and 1H NMR respectively.
出处
《宜宾学院学报》
2010年第6期68-70,共3页
Journal of Yibin University
基金
宜宾学院青年基金项目(2008QJ33
2008QJ30)
