摘要
对３６３例２型糖尿病先证者家系及２９１例人群对照家系进行了以人群为基础的遗传流行病学病例－对照研究。结果显著的：糖尿病先证者一级亲属（父母、同胞、子女）的累积发病率为３．９４％，对照组一级亲属１．０９％，相对危险度（ＲＲ）为３．６２，差异有非常显著性意义（χ２＝３６．５４，Ｐ＜０．００１）；无论男性或女性一级亲属，先证者组的累积发病率均非常显著地高于人群对照组；诊断时年龄＜５５岁先证者的一级亲属，其糖尿病累积发病率和相对危险度均显著高于诊断年龄＞５５岁组。二项分布显示先证者一级亲属中２型糖尿病的分布呈明显的家庭聚集性，先证者一级亲属的遗传度为４０．４％（男性４２．６％，女性３８．６％）；２型糖尿病在同胞中的分离比为０．０３２，显著低于０．２５，不符合单基因遗传的特征。
A population based case control family study including 654 pedigrees(363 index cases and 291 population controls)was carried out to explore the role of genetic agent on the development of type 2 diabetes mellitus (DM).The results showed that the cumulative incidence rate of the first degree relatives in cases was 3.94%,significantly higher than that in controls(1.10%).The relative risk(RR)of DM in probands' pedigrees was 3.62(χ 2=36.5,P<0.001).The same results were also found in their female and male relatives.The cumulative incidence rates and RR among relatives of probands aged less than 55 years old were significantly higher than that of probands aged more than 55 years old.Results from binominal distribution analysis showed that there was significant famillial aggregation in the occurance of DM in the first degree relatives in cases.Hertability in the first degree relatives of diabetes probands was 40.6%(male 42.6%,female 38.6%).The segregation ratio of DM was 0.032,which was significantly lower than 0.25,and met the features of polygenic diseases.
出处
《中国公共卫生》
CAS
CSCD
北大核心
1999年第6期492-494,共3页
Chinese Journal of Public Health
关键词
糖尿病
遗传病因
流行病学
Type 2 diabetes mellitus\ Segregation ratio Genetic epidemiology Heritability
