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组蛋白去乙酰化酶抑制剂SAHA的合成研究 被引量：2

Synthesis of histone deacetylase inhibitor SAHA
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摘要 目的:改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。方法:以辛二酸为起始原料,经缩合、活化、氨解合成SAHA。结果:经3步反应得到目标化合物。结论:改进后的合成工艺简便、条件温和、原料易得。 Objective： To improve the synthetic procedure of the histone deacetylase（HDAC） inhibitor SAHA.Methods： Suberic acid was selected as the start material,and the SAHA was obtained through condensation,activation and ammoniated.Results： The final product was synthesized in 3 steps.Conclusions： The modified synthetic procedure is with easily obtained material,mild conditions and convenient operation.
作者 周忻
机构地区 解放军总医院药品保障中心中药房
出处 《海南医学院学报》 CAS 2010年第10期1259-1260,共2页 Journal of Hainan Medical University
基金 海南医学院科研基金资助学报项目(0020100353)~~
关键词 组蛋白去乙酰化酶抑制剂 抗肿瘤药物 SAHA 合成 HDAC inhibitor Anticancer drug SAHA Synthesis
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

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同被引文献21

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海南医学院学报
2010年 第10期

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